Data Catalog

• Federal

  Extrapolating In Vitro and Ex Vivo Screening Assay Data for Thyroperoxidase Inhibition to Predict Serum Thyroid Hormones in the Rat

  U.S. Environmental Protection Agency —

  This data set is a dose response analysis of two thyroid hormone synthesis disruptors in adult male rats. Data included serum and thyroid gland concentrations of the...

  • XLS
• Federal

  Targeted pathway-based in vivo testing using thyroperoxidase inhibition to evaluate plasma thyroxine as a surrogate metric of metamorphic success in model amphibian Xenopus laevis

  U.S. Environmental Protection Agency —

  These data are represented in tables and graphs in the article, "Targeted pathway-based in vivo testing using thyroperoxidase inhibition to evaluate plasma thyroxine...

  • XLS
• Federal

  Quantitative Adverse Outcome Pathway for Neurodevelopmental Effects of Thyroid Peroxidase-Induced Thyroid Hormone Synthesis Inhibition

  U.S. Environmental Protection Agency —

  Adequate levels of thyroid hormones (TH) are needed for proper brain development, deficiencies may lead to adverse neurological outcomes in humans and animal models....

  • XLS
• Federal

  Data from Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors within the ToxCast Phase I and II Chemical Libraries

  U.S. Environmental Protection Agency —

  High-throughput screening for potential thyroid-disrupting chemicals requires a system of assays to capture multiple molecular-initiating events (MIEs) that converge...

  • DOC
  • HTML

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