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Federal
Expression data from C. elegans
National Aeronautics and Space Administration —
We used microarrays to investigate the effects of microgravity and space radiation on the genome-wide expression of the C. elegans. Three technical replicates of wild... -
Federal
Age and Space Irradiation Modulate Tumor Progression: Implications for Carcinogenesis Risk
National Aeronautics and Space Administration —
Age plays a major role in tumor incidence and is an important consideration when modeling the carcinogenesis process or estimating cancer risks. Epidemiological data... -
Federal
The Arabidopsis spaceflight transcriptome: a comparison of whole plants to discrete root hypocotyl and shoot responses to the orbital environment
National Aeronautics and Space Administration —
Arabidopsis thaliana was evaluated for its response to the spaceflight environment in three replicated experiments on the International Space Station. Two approaches... -
Federal
MESSAGE 2 space experiment with Rhodospirillum rubrum S1H
National Aeronautics and Space Administration —
R. rubrum S1H inoculated on solid agar rich media was sent to the ISS in October 2003 (MESSAGE-part 2 experiment). After 10 days flight R. rubrum cultures returned... -
Federal
The Arabidopsis spaceflight transcriptome: a comparison of whole plants to discrete root hypocotyl and shoot responses to the orbital environment
National Aeronautics and Space Administration —
Arabidopsis thaliana was evaluated for its response to the spaceflight environment in three replicated experiments on the International Space Station. Two approaches... -
Federal
Low dose ionizing radiation treated lymphoblastoid cells
National Aeronautics and Space Administration —
Irradiated cell lines exposed to 1-10 cGy 2 Lymphoblastoid cell lines (GM15510 and GM15036) irradiated 1 2.5 5 7.5 10 cGy RNA is isolated and labeled using a T7... -
Federal
Dynamic gene expression response to altered gravity in human T cells (sounding rocket flight)
National Aeronautics and Space Administration —
We investigated differentially regulated genes in human Jurkat T lymphocytic cells in 20s and 5min microgravity and in hypergravity and compared expression profiles... -
Federal
HSFA2 functions in the physiological adaptation of undifferentiated plant cells to spaceflight microgravity environment
National Aeronautics and Space Administration —
The Heat Shock Factor A2 (HsfA2) as a part of the HSF network is essential to the plant s response to almost any environmental stress and to the cellular homeostatic... -
Federal
Expression data from C. elegans
National Aeronautics and Space Administration —
We used microarrays to investigate the effects of microgravity and space radiation on the genome-wide expression of the C. elegans. Three technical replicates of wild... -
Federal
Identifying radiation exposure biomarkers from mouse blood transcriptome
National Aeronautics and Space Administration —
Here we present a whole-genome survey of the murine transcriptomic response to physiologically-relevant radiation doses 2 and 8 Gy. There are 18 distinct biological... -
Federal
Transient gene expression profile changes of confluent human fibroblast cells in spaceflight
National Aeronautics and Space Administration —
Microgravity or an altered gravity environment from the static 1g has been shown to influence global gene expression patterns and protein levels in cultured cells or... -
Federal
Rodent Research-1 (RR1) NASA Validation Flight: Mouse gastrocnemius muscle transcriptomic proteomic and epigenomic data
National Aeronautics and Space Administration —
NASA s Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited... -
Federal
Gene responses in mouse brain to long-term exposure to microgravity
National Aeronautics and Space Administration —
The spaceflight experiment was carried out using male C57BL/10J mice (8 weeks old at launch). Wild type mice (n=3) were launched by Space Shuttle Discovery and housed... -
Federal
Genechip analysis of bone marrow osteoprogenitors exposed to microgravity
National Aeronautics and Space Administration —
In March 2006 murine Bone Marrow Stromal Cells (BMSC) were flown in the Soyuz 12S to the International Space Station to investigate the effects of microgravity on... -
Federal
Transcription profiling of Drosophila after exposure to microgravity in the International Space Station and in a microgravity simulator
National Aeronautics and Space Administration —
Larvae-Pupae transition flies (Drosophila) were recovered and transport for 3 days at 12-14C to arrest development until the launch site then exposed to RT (18-20C)... -
Federal
Galactic cosmic radiation induces stable epigenome alterations relevant to human lung cancer
National Aeronautics and Space Administration —
Human deep space and planetary travel is limited by uncertainties regarding the health risks associated with exposure to galactic cosmic radiation (GCR) and in... -
Federal
Transcription profiling of human MCF10A cells subjected to ionizing radiation and treatment with transforming growth factor beta-1
National Aeronautics and Space Administration —
Transforming growth factor beta-1 (TGFbeta) is a tumor suppressor during the initial stage of tumorigenesis but it can switch to a tumor promoter during neoplastic... -
Federal
Multi-omic investigations of mouse liver subjected to simulated spaceflight freezing and storage protocols
National Aeronautics and Space Administration —
This study compares standard laboratory protocols for tissue freezing and storage with a simulation of the delayed processing of liver specimens and long-term storage... -
Federal
IMR90 radiation bystander time-course experiment 0.5Gy alpha particle
National Aeronautics and Space Administration —
The radiation bystander effect is an important component of the overall biological response of tissues and organisms to ionizing radiation. Little is known about the... -
Federal
Global gene expression analysis highlights microgravity sensitive key genes in soleus and EDL of 30 days space flown mice
National Aeronautics and Space Administration —
Microgravity exposure as well as chronic muscle disuse are two of the main causes of physiological adaptive skeletal muscle atrophy in humans and murine animals in...