14 datasets found
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Federal
Androgen and retinoic acid interaction in LNCaP cells, effects on cell proliferation and expression of retinoic acid receptors and epidermal growth factor receptor
U.S. Department of Health & Human Services —
Background Modulation of the expression of retinoic acid receptors (RAR) α and γ in adult rat prostate by testosterone (T) suggests that RAR signaling events might... -
Federal
Datasets used in ORD-023417: Identification of Androgen Receptor Modulators in a Prostate Cancer Cell Line Microarray Compendium
U.S. Environmental Protection Agency —
Datasets used in ORD-023417: Identification of Androgen Receptor Modulators in a Prostate Cancer Cell Line Microarray Compendium. This dataset is associated with the... -
Federal
Cross-species molecular docking method to support predictions of species susceptibility to chemical effects
U.S. Environmental Protection Agency —
The advancement of protein structural prediction tools, exemplified by AlphaFold and Iterative Threading ASSEmbly Refinement, has enabled the prediction of protein... -
Federal
RJudson_Mansouri_CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity
U.S. Environmental Protection Agency —
Data and supplemental files from COMPARA (A large-scale modeling project). COMPARA combined multiple models developed in collaboration with modelers and computational... -
Federal
Development, validation and integration of in silico models to identify androgen active chemicals
U.S. Environmental Protection Agency —
A diverse data set of 1667 chemicals with AR experimental activity were provided by the U.S. EPA from the oxicity Forecaster (ToxCast) program which generates data... -
Federal
Adverse Outcome Pathway Network-Based Assessment of the Interactive Effects of an Androgen Receptor Agonist and an Aromatase Inhibitor on Fish Endocrine Function
U.S. Environmental Protection Agency —
Adverse outcome pathway (AOP) networks potentially provide a basis for predictive approaches to assess the toxicity of chemical mixtures. This study evaluated the... -
Federal
A study of temporal effects of the model anti-androgen flutamide on components of the hypothalamic-pituitary-gonadal axis in adult fathead minnows
U.S. Environmental Protection Agency —
The aim of this study was to investigate temporal changes in the hypothalamic-pituitary-gonadal axis of fathead minnow treated with the model androgen receptor (AR)... -
Federal
Weight of evidence for cross-species conservation of androgen receptor-based biological activity
U.S. Environmental Protection Agency —
Figures, tables, data for "Sara M F Vliet, Kristan J Markey, Scott G Lynn, Anna Adetona, Dawn Fallacara, Patricia Ceger, Neepa Choksi, Agnes L Karmaus, AtLee Watson,... -
Federal
Selecting a Minimal set of Androgen Receptor Assays for Screening Chemicals
U.S. Environmental Protection Agency —
Screening certain environmental chemicals for their ability to interact with endocrine targets, including the androgen receptor (AR), is an important global concern.... -
Federal
Datasets in Gene Expression Omnibus used in the study ORD-020969: Genomic effects of androstenedione and sex-specific liver cancer susceptibility in mice
U.S. Environmental Protection Agency —
Datasets in Gene Expression Omnibus used in the study ORD-020969: Genomic effects of androstenedione and sex-specific liver cancer susceptibility in mice. This... -
Federal
IN VITRO AND IN VIVO ANDROGEN RECEPTOR DATA SET FROM TOX SCI PAPER GRAY ET AL 2020
U.S. Environmental Protection Agency —
Data sets include 1. Excel file with Hershberger assay protocols and data and summaries of in vivo antiandrogen studies 2. Figures of in vitro AR assay results from... -
Federal
High-throughput AR dimerization assay identifies androgen disrupting chemicals and metabolites
U.S. Environmental Protection Agency —
Repository for supplemental files and code for paper titled "High-throughput AR Dimerization Assay Identifies Androgen Disrupting Chemicals and Metabolites", 2022.... -
Federal
Predictive Structure-Based Toxicology Approaches To Assess the Androgenic Potential of Chemicals
U.S. Environmental Protection Agency —
Chemical structures, RMSD values, docking scores, additional tables and figures, and methodological details (PDF) Additional information concerning the starting data... -
Federal
Combining in vitro and in silico New Approach Methods to investigate type 3 iodothyronine deiodinase chemical inhibition across species
U.S. Environmental Protection Agency —
Dataset for "Combining in vitro and in silico New Approach Methods to investigate type 3 iodothyronine deiodinase chemical inhibition across species". This dataset is...
14 datasets found