27 datasets found
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Federal
Datasets associated with journal article 'Combining phenotypic profiling and targeted RNA-Seq reveals linkages between transcriptional perturbations and chemical effects on cell morphology: Retinoic acid as an example' by Nyffeler, J, et.al. recent views
U.S. Environmental Protection Agency —
We evaluated the Templated Oligo with Sequencing Readout (TempO-Seq) assay for High-throughput transcriptomic screening of a small set of environmental chemicals.... -
Federal
The Residential Population Generator (RPGen): A tool to parameterize residential, demographic, and physiological data to model intraindividual exposure, dose, and risk recent views
U.S. Environmental Protection Agency —
This repository contains scripts, input files, and some example output files for the Residential Population Generator, an R-based tool to generate synthetic human... -
Federal
High-Throughput Transcriptomics Platform for Screening Environmental Chemicals recent views
U.S. Environmental Protection Agency —
We screened 44 chemicals in MCF7 cells in concentration response and generated HTTr data using the TempO-Seq hWTv1 assay. First, we provide an outline of the quality... -
Federal
Phenotypic Profiling of Reference Chemicals across Biologically Diverse Cell Types Using the Cell Painting Assay recent views
U.S. Environmental Protection Agency —
Cell Painting is a high-throughput, phenotypic profiling assay that uses fluorescent cytochemistry o visualize a variety of organelles and high-content imaging to... -
Federal
Chemical agnostic hazard prediction: Statistical inference of toxicity pathways - data for Figure 2 recent views
U.S. Environmental Protection Agency —
This dataset comprises one SigmaPlot 13 file containing measured survival data and survival data predicted from the model coefficients selected by the LASSO... -
Federal
The CompTox Chemistry Dashboard: a community data resource for environmental chemistry recent views
U.S. Environmental Protection Agency —
The contents of the chemistry database, presently containing ~ 760,000 substances, are available as public domain data for download. The chemistry content... -
Federal
Integrating Data From In Vitro New Approach Methodologies for Developmental Neurotoxicity recent views
U.S. Environmental Protection Agency —
This dataset consists of data from in vitro developmental neurotoxicity new approach methodologies (DNT-NAMs). Assays include evaluations of proliferation, apoptosis,... -
Federal
High-Throughput Transcriptomics Screen of ToxCast Chemicals in U-2 OS Cells recent views
U.S. Environmental Protection Agency —
Supplemental datafiles for journal article 'High-Throughput Transcriptomics Screen of ToxCast Chemicals in U-2 OS Cells'. -
Federal
SSDn insecticide dataset recent views
U.S. Environmental Protection Agency —
This is a dataset of acute toxicity values for organophosphate and carbamate insecticides. the dataset is used to develop and validate the species sensitivity... -
Federal
SEQUENCING AND DE NOVO DRAFT ASSEMBLIES OF A FATHEAD MINNOW (Pimpehales promelas) reference genome recent views
U.S. Environmental Protection Agency —
The dataset provides the URLs for accessing the genome sequence data and two draft assemblies as well as fathead minnow genotyping data associated with estimating the... -
Federal
Optimization of Human Neural Progenitor Cells for an Imaging-Based High-Throughput Phenotypic Profiling Assay for Developmental Neurotoxicity Screening recent views
U.S. Environmental Protection Agency —
Dataset for article ‘Optimization of Human Neural Progenitor Cells for an Imaging-Based High-Throughput Phenotypic Profiling Assay for Developmental Neurotoxicity... -
Federal
Comparison of Approaches for Determining Bioactivity Hits from High-Dimensional Profiling Data recent views
U.S. Environmental Protection Agency —
** Note to Josh Harrill- I don't have a copy of the final manuscript so could you please add the description of this dataset (just delete this comment and enter or... -
Federal
Evaluation of food-relevant chemicals in the ToxCast high-throughput screening program recent views
U.S. Environmental Protection Agency —
Thousands of chemicals are directly added to or come in contact with food, many of which have undergone little to no toxicological evaluation. The landscape of the... -
Federal
Pilot testing and optimization of a larval fathead minnow high throughput transcriptomics assay recent views
U.S. Environmental Protection Agency —
The present study describes pilot testing of a high throughput compatible transcriptomics assay with larval fathead minnows. One day post hatch fathead minnows were... -
Federal
Probabilistic modelling of developmental neurotoxicity based on a simplified adverse outcome pathway network recent views
U.S. Environmental Protection Agency —
Table of contents Table S1 DNT inventory List of sources and associated data collected for the development of the Bayesian hierarchical model. Table S2 Data... -
Federal
Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space recent views
U.S. Environmental Protection Agency —
Chemical toxicity can arise from disruption of specific biomolecular functions or through more generalized cell stress and cytotoxicity-mediated processes. Here,... -
Federal
Bioactivity screening of environmental chemicals using imaging-based high-throughput phenotypic profiling recent views
U.S. Environmental Protection Agency —
In the present study, we adapted an existing phenotypic profiling assay (“Cell Painting”, (Bray et al., 2016)) to be compatible with in-house microfluidics... -
Federal
Estimating provisional margins of exposure for data-poor chemicals using high-throughput computational methods recent views
U.S. Environmental Protection Agency —
Dataset for "Nicolas Chantel I., Linakis Matthew W., Minto Melyssa S., Mansouri Kamel, Clewell Rebecca A., Yoon Miyoung, Wambaugh John F., Patlewicz Grace, McMullen... -
Federal
From Protein Sequence to Structure: The Next Frontier in Cross-Species Extrapolation for Chemical Safety Evaluations recent views
U.S. Environmental Protection Agency —
Supplemental data for "LaLone CA, Blatz DJ, Jensen MA, Vliet SMF, Mayasich S, Mattingly KZ, Transue TR, Melendez W, Wilkinson A, Simmons CW, Ng C, Zhang C, Zhang Y.... -
Federal
Evaluating adaptive stress response gene signatures using transcriptomics- Data for Figures 1-4 recent views
U.S. Environmental Protection Agency —
The construction of SRP consensus signatures sets was completed in three steps. First, we constructed consensus signatures by merging and pruning relevant gene sets...
27 datasets found