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Federal
Compulsive checking behavior of quinpirole-sensitized rats as an animal model of Obsessive-Compulsive Disorder(OCD): form and control
U.S. Department of Health & Human Services —
Background A previous report showed that the open field behavior of rats sensitized to the dopamine agonist quinpirole satisfies 5 performance criteria for compulsive... -
Federal
Delayed union of femoral fractures in older rats:decreased gene expression
U.S. Department of Health & Human Services —
Background Fracture healing slows with age. While 6-week-old rats regain normal bone biomechanics at 4 weeks after fracture, one-year-old rats require more than 26... -
Federal
The effectiveness of reducing the daily dose of finasteride in men with benign prostatic hyperplasia
U.S. Department of Health & Human Services —
Background Finasteride, a 5 alpha reductase inhibitor, is an established treatment for benign prostatic hyperplasia. The recommended dosage is 5 mg a day, however... -
Federal
Appetite suppressants and valvular heart disease – a systematic review
U.S. Department of Health & Human Services —
Background Although appetite suppressants have been implicated in the development of valvular heart disease, the exact level of risk is still uncertain. Initial... -
Federal
Plasma colloid osmotic pressure in healthy infants
U.S. Department of Health & Human Services —
Background The plasma colloid osmotic pressure (COP) plays a major role in transcapillary fluid balance. There is no information on plasma COP of healthy infants... -
Federal
Antigen-specific cytometry
U.S. Department of Health & Human Services —
From its origins in the 16thcentury, microscopy has allowed the cell, as the basic unit of eukaryotic life and disease, to be identified and analyzed. Today,... -
Federal
Application of the development stages of a cluster randomized trial to a framework for evaluating complex health interventions
U.S. Department of Health & Human Services —
Introduction Trials of complex health interventions often pose difficult methodologic challenges. The objective of this paper is to assess the extent to which the... -
Federal
Case-oriented computer-based-training in radiology: concept, implementation and evaluation
U.S. Department of Health & Human Services —
Background Providing high-quality clinical cases is important for teaching radiology. We developed, implemented and evaluated a program for a university hospital to... -
Federal
Time course of muscle soreness following different types of exercise
U.S. Department of Health & Human Services —
Background Post-exercise muscle soreness is a dull, aching sensation that follows unaccustomed muscular exertion. Primarily on the basis of previous laboratory-based... -
Federal
Genetic epidemiology: Systemic lupus erythematosus
U.S. Department of Health & Human Services —
Systemic lupus erythematosus is the prototype multisystem autoimmune disease. A strong genetic component of susceptibility to the disease is well established. Studies... -
Federal
Results of a phase-I/II randomized, masked, placebo-controlled trial of recombinant human interleukin-11 (rhIL-11) in the treatment of subjects with active rheumatoid arthritis
U.S. Department of Health & Human Services —
Interleukin-11 (IL-11) is a pleiotropic cytokine that regulates the growth and development of hematopoietic stem cells and decreases the proinflammatory mediators of... -
Federal
Autocrine regulation of asthmatic airway inflammation: role of airway smooth muscle
U.S. Department of Health & Human Services —
Chronic airway inflammation is one of the main features of asthma. Release of mediators from infiltrating inflammatory cells in the airway mucosa has been proposed to... -
Federal
Bone mineral density and the subsequent risk of cancer in the NHANES I follow-up cohort
U.S. Department of Health & Human Services —
Backgroud Bone mineral density (BMD) is a marker of long-term estrogen exposure. BMD measurement has been used in this context to investigate the association of... -
Federal
Acetaminophen toxicity: suicidal vs accidental
U.S. Department of Health & Human Services —
Introduction Acetaminophen toxicity, which can lead to hepatotoxicity, is a burden on our health care system and contributes significantly to intensive care unit... -
Federal
Penis size: Survey of female perceptions of sexual satisfaction
U.S. Department of Health & Human Services —
Background Does the size of the male penis, in terms of length or width, make a difference in female sexual satisfaction? Method To study the effect of penis width... -
Federal
A comparison of volume control and pressure-regulated volume control ventilation in acute respiratory failure
U.S. Department of Health & Human Services —
Background: The aim of this study was to test the hypothesis that a new mode of ventilation (pressure-regulated volume control; PRVC) is associated with improvements... -
Federal
Cellular senescence:ex vivop53-dependent asymmetric cell kinetics
U.S. Department of Health & Human Services —
Cellular senescence is a defining property of euploid cells in culture [1,2]. Cultures derived from cells explanted from tissues of a variety of animal species... -
Federal
Binding specificity of
U.S. Department of Health & Human Services —
Background To better understand the molecular interactions of Bt toxins with non-target insects, we have examined the real-time binding specificity and affinity of... -
Federal
Transcutaneous flow related variables measured in vivo: the effects of gender
U.S. Department of Health & Human Services —
Backgound The identification of potential sources of error is a crucial step for any new assessment technique. This is the case for transcutaneous variables, such as... -
Federal
Insertion of a small peptide of six amino acids into the β7–β8 loop of the p51 subunit of HIV-1 reverse transcriptase perturbs the heterodimer and affects its activities
U.S. Department of Health & Human Services —
Background HIV-1 RT is a heterodimeric enzyme, comprising of the p66 and p51 subunits. Earlier, we have shown that the β7-β8 loop of p51 is a key structural element...