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Federal
Lack of agreement between tonometric and gastric juice partial carbon dioxide tension
U.S. Department of Health & Human Services —
Our goal was to compare measurement of tonometered saline and gastric juice partial carbon dioxide tension (PCO2). In this prospective observational study, 112 pairs... -
Federal
The viral transmembrane superfamily: possible divergence of Arenavirus and Filovirus glycoproteins from a common RNA virus ancestor
U.S. Department of Health & Human Services —
Background Recent studies of viral entry proteins from influenza, measles, human immunodeficiency virus, type 1 (HIV-1), and Ebola virus have shown, first with... -
Federal
Simultaneous identification of
U.S. Department of Health & Human Services —
Background The glutathione S-transferase (GST) enzyme GSTP1 utilizes byproducts of oxidative stress. We previously showed that alleles of GSTP1 that encode the... -
Federal
Di-, tri- and tetra-5'-
U.S. Department of Health & Human Services —
Background The human FHIT gene is inactivated early in the development of many human cancers and loss of Fhit in mouse predisposes to cancer while reintroduction of... -
Federal
Impact of renal dysfunction on weaning from prolonged mechanical ventilation
U.S. Department of Health & Human Services —
Background: In the intensive care unit (ICU) setting, the combination of mechanical ventilation and renal replacement therapy (RRT) has been associated with prolonged... -
Federal
Reviewing the reviewers: the vague accountability of research ethics committees
U.S. Department of Health & Human Services —
The role of research ethics committees (RECs) is currently strained by increases in the number of protocols that are in need of review, the scientific and funding... -
Federal
Locations of several novel 2'-
U.S. Department of Health & Human Services —
Background Ribose 2'-O-methylation, the most common nucleotide modification in mammalian rRNA, is directed by the C/D box small nucleolar RNAs (snoRNAs). Thus far,... -
Federal
Interactions of pathogens and irritant chemicals in land-applied sewage sludges (biosolids)
U.S. Department of Health & Human Services —
Background Fertilisation of land with processed sewage sludges, which often contain low levels of pathogens, endotoxins, and trace amounts of industrial and household... -
Federal
Inhibition of the MEK1/ERK pathway reduces arachidonic acid release independently of cPLA
U.S. Department of Health & Human Services —
Background The 85-kDa cytosolic phospholipase A2 (cPLA2) mediates arachidonic acid (AA) release in MDCK cells. Although calcium and mitogen-activated protein kinases... -
Federal
Central effects of clozapine in regulating micturition in anesthetized rats
U.S. Department of Health & Human Services —
Background We previously showed that systemic administration of the atypical neuroleptic clozapine in the rat altered a number of urodynamic variables and inhibited... -
Federal
Delta-opioid receptor endocytosis in spinal cord after dermenkephalin activation
U.S. Department of Health & Human Services —
Background The delta(δ)-opioid receptors belong to the G protein-coupled receptors and in vitro studies have shown that δ-opioid receptors undergo an internalization... -
Federal
Predictors of positive health in disability pensioners: a population-based questionnaire study using Positive Odds Ratio
U.S. Department of Health & Human Services —
Background Determinants of ill-health have been studied far more than determinants of good and improving health. Health promotion measures are important even among... -
Federal
Outcomes research in the development and evaluation of practice guidelines
U.S. Department of Health & Human Services —
Background Practice guidelines have been developed in response to the observation that variations exist in clinical medicine that are not related to variations in the... -
Federal
Synovial cytokine mRNA expression during arthritis triggered by CpG motifs of bacterial DNA
U.S. Department of Health & Human Services —
Our results show that cytokines derived from macrophages play an important role in pathogenesis of arthritis triggered by CpG oligodinucleotide (CpG ODN). IL-12 is in... -
Federal
Pharmacological and ischemic preconditioning of the human myocardium: mitoK
U.S. Department of Health & Human Services —
Background These studies investigate the role of mitoKATP channels, protein kinase C (PKC) and Mitogen activated protein kinase (p38MAPK) on the cardioprotection of... -
Federal
Differential response to right unilateral ECT in depressed patients: impact of comorbidity and severity of illness [ISRCTN39974945]
U.S. Department of Health & Human Services —
Background Recent electroconvulsive therapy (ECT) efficacy studies of right unilateral (RUL) ECT may not apply to real life clinics with a wide range of patients with... -
Federal
PCR primers for an aldolase-B intron in acanthopterygian fishes
U.S. Department of Health & Human Services —
Background Nuclear DNA sequences provide genetic information that complements studies using mitochondrial DNA. Some 'universal' primer sets have been developed that... -
Federal
Rational therapy of chronic venous insufficiency – chances and limits of the therapeutic use of horse-chestnut seeds extract
U.S. Department of Health & Human Services —
Background and methods We report two clinical studies, one already published, performed in patients with early and advanced chronic venous insufficiency (CVI). In... -
Federal
The intronic G13964C variant in
U.S. Department of Health & Human Services —
Background Mutations in BRCA1 and BRCA2 account for approximately 50% of breast cancer families with more than four affected cases, whereas exonic mutations in p53,... -
Federal
Differential localization in cells of myosin II heavy chain kinases during cytokinesis and polarized migration
U.S. Department of Health & Human Services —
Background Cortical myosin-II filaments in Dictyostelium discoideum display enrichment in the posterior of the cell during cell migration and in the cleavage furrow...