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Federal
Taking stock of gene therapy for cystic fibrosis
U.S. Department of Health & Human Services —
The identification of the cystic fibrosis (CF) gene opened the way for gene therapy. In the ten years since then, proof of principle in vitro and then in animal... -
Federal
Reporting of adverse drug reactions in randomised controlled trials – a systematic survey
U.S. Department of Health & Human Services —
Background Decisions on treatment are guided, not only by the potential for benefit, but also by the nature and severity of adverse drug reactions. However, some... -
Federal
Survey of the knowledge, attitude and practice of Nigerian surgery trainees to HIV-infected persons and AIDS patients
U.S. Department of Health & Human Services —
Background The incidence of HIV infection and AIDS is rising in Nigeria. Surgeons are at risk of occupationally acquired infection as a result of intimate contact... -
Federal
Twenty-four hour presence of physicians in the ICU
U.S. Department of Health & Human Services —
Intensive-care units (ICUs) must be utilised in the most efficient way. Greater input of intensivists leads to better outcomes and more efficient use of resources.... -
Federal
A theoretical approach to predicting the success of genetic manipulation of malaria mosquitoes in malaria control
U.S. Department of Health & Human Services —
Background Mosquitoes that have been genetically modified to better encapsulate the malaria parasite Plasmodium falciparum are being considered as a possible tool in... -
Federal
Socio-demographic factors and self-reported funtional status: the significance of social support
U.S. Department of Health & Human Services —
Background The aim of the present work was to investigate the relative importance of socio-demographic and physical health status factors for subjective functioning,... -
Federal
Assessment of the infectious diseases surveillance system of the Republic of Armenia: an example of surveillance in the Republics of the former Soviet Union
U.S. Department of Health & Human Services —
Background Before 1991, the infectious diseases surveillance systems (IDSS) of the former Soviet Union (FSU) were centrally planned in Moscow. The dissolution of the... -
Federal
Hormone replacement therapy and prevention of vertebral fractures: a meta-analysis of randomised trials
U.S. Department of Health & Human Services —
Background Hormone replacement therapy (HRT) is often seen as the treatment of choice for preventing fractures in women. We undertook a recent meta-analysis of... -
Federal
A comparison of hospital readmission rates between two general physicians with different outpatient review practices
U.S. Department of Health & Human Services —
Background There has been a relentless increase in emergency medical admissions in the UK over recent years. Many of these patients suffer with chronic conditions... -
Federal
Breast cancer mortality among Ashkenazi Jewish women in São Paulo and Porto Alegre, Brazil
U.S. Department of Health & Human Services —
Background Increased BRCA1 and BRCA2 germline mutation rates have been reported in Ashkenazi Jewish women in North America, Europe and Israel, and have been mentioned... -
Federal
Bone loss: Epidemiology of bone loss
U.S. Department of Health & Human Services —
Bone loss occurs when the cellular events of bone formation are quantitatively larger than bone formation. This manuscript discusses the measurement of bone loss,... -
Federal
The MRC trial of assessment and management of older people in the community: objectives, design and interventions [ISRCTN23494848]
U.S. Department of Health & Human Services —
Background The benefit of regular multidimensional assessment of older people remains controversial. The majority of trials have been too small to produce adequate... -
Federal
A surrogate-based approach for post-genomic partner identification
U.S. Department of Health & Human Services —
Background Modern drug discovery is concerned with identification and validation of novel protein targets from among the 30,000 genes or more postulated to be present... -
Federal
Paper reports overview: The many guises of respiratory support, microalbuminuria and delirium
U.S. Department of Health & Human Services —
Paper reports overview: The many guises of respiratory support, microalbuminuria and delirium -
Federal
Influence of twenty-five per cent human serum albumin on total and ionized calcium concentrations
U.S. Department of Health & Human Services —
Background: A inverse correlation has been found between changes in ionized calcium concentrations and the addition of albumin in vitro, which may explain adverse... -
Federal
The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients
U.S. Department of Health & Human Services —
Objective To estimate the mortality and length of stay in the intensive care unit (ICU) attributable to clinically important gastrointestinal bleeding in mechanically... -
Federal
Reduction of post injury neointima formation due to 17β-estradiol and phytoestrogen treatment is not influenced by the pure synthetic estrogen receptor antagonist ICI 182,780 in vitro
U.S. Department of Health & Human Services —
Background Animal and organ culture experiments have shown beneficial inhibitory estrogen effects on post injury neointima development. The purpose of this study was... -
Federal
What you should know about PR3-ANCA: Structural aspects of antibodies to proteinase 3 (PR3)
U.S. Department of Health & Human Services —
Reactive antigenic epitopes on presumed autoantigens of biologic interest have been examined by many researchers. The central third complementarity-determining region... -
Federal
A draft annotation and overview of the human genome
U.S. Department of Health & Human Services —
Background The recent draft assembly of the human genome provides a unified basis for describing genomic structure and function. The draft is sufficiently accurate to... -
Federal
Endovascular treatment of huge saccular abdominal aortic aneurysm in a young Behcet patient: mid-term result
U.S. Department of Health & Human Services —
Background Abdominal aortic aneurysm formation is among the arterial complications of Behcet's disease. Weakness and fragility of aortic walls leads to the...