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Federal
Genetics of osteoarticular disorders, Florence, Italy, 22–23 February 2002
U.S. Department of Health & Human Services —
Osteoporosis (OP) and osteoarthritis (OA), the two most common age-related chronic disorders of articular joints and skeleton, represent a major public health problem... -
Federal
Bridging case-control studies and randomized trials
U.S. Department of Health & Human Services —
Randomized trials and observational studies, such as case-control studies, are often seen as opposing approaches. However, in many instances results obtained by... -
Federal
'CFTR-opathies': disease phenotypes associated with cystic fibrosis transmembrane regulator gene mutations
U.S. Department of Health & Human Services —
Cystic fibrosis is a genetic disease that is associated with abnormal sweat electrolytes, sino-pulmonary disease, exocrine pancreatic insufficiency, and male... -
Federal
Binding specificity of
U.S. Department of Health & Human Services —
Background To better understand the molecular interactions of Bt toxins with non-target insects, we have examined the real-time binding specificity and affinity of... -
Federal
Drug-induced and postnatal hypothyroidism impairs the accumulation of diacylglycerol in liver and liver cell plasma membranes
U.S. Department of Health & Human Services —
Background Thyroid hormones are well known modulators of signal transduction. The effect of hyper- and hypo-thyroidism on diacylglycerol/protein kinase C (DAG/PKC)... -
Federal
The human Y chromosome: the biological role of a “functional wasteland”
U.S. Department of Health & Human Services —
“Functional wasteland,” “Nonrecombining desert,” and “Gene-poor chromosome” are only some examples of the different definitions given to the Y chromosome in the last... -
Federal
Retrovirus-delivered siRNA
U.S. Department of Health & Human Services —
The ability of transfected synthetic small interfering (si) RNAs to suppress the expression of specific transcripts has proved a useful technique to probe gene... -
Federal
What have transgenic and knockout animals taught us about respiratory disease?
U.S. Department of Health & Human Services —
Over the past decade there has been a significant shift to the use of murine models for investigations into the molecular basis of respiratory diseases, including... -
Federal
Transcutaneous flow related variables measured in vivo: the effects of gender
U.S. Department of Health & Human Services —
Backgound The identification of potential sources of error is a crucial step for any new assessment technique. This is the case for transcutaneous variables, such as... -
Federal
Possible association of β
U.S. Department of Health & Human Services —
Background The involvement of β2-adrenergic receptor (ADRB2) and β3-adrenergic receptor (ADRB3) in both adipocyte lipolysis and thermogenic activity suggests that... -
Federal
Estrogen receptor alpha dinucleotide repeat polymorphism in Japanese patients with autoimmune thyroid diseases
U.S. Department of Health & Human Services —
Background The autoimmune thyroid diseases (AITDs), comprising Graves' disease (GD) and Hashimoto's thyroiditis (HT), appear to develop as a result of complex... -
Federal
Pleasure in decision-making situations
U.S. Department of Health & Human Services —
Background This study explores the role of pleasure in decision making. Results In Experiment 1, 12 subjects were presented with a questionnaire containing 46 items... -
Federal
Imiquimod for the treatment of genital warts: a quantitative systematic review
U.S. Department of Health & Human Services —
Objective To review published randomised controlled trials to assess the benefit and harm of imiquimod in the treatment of external genital warts. Data sources... -
Federal
Antinociceptive and anti-inflammatory effects of
U.S. Department of Health & Human Services —
Background Crocus sativus L. (saffron) is used in folk medicine, for example as an antiedematogenic agent. We aimed to evaluate the antinociceptive and anti-... -
Federal
Debate: Subgroup analyses in clinical trials: fun to look at - but don't believe them!
U.S. Department of Health & Human Services —
Analysis of subgroup results in a clinical trial is surprisingly unreliable, even in a large trial. This is the result of a combination of reduced statistical power,... -
Federal
Low frequency of
U.S. Department of Health & Human Services —
In order to explore the possible role of E-cadherin in familial cancer, 19 familial breast cancer patients, whose tumours demonstrated loss of heterozygosity (LOH) at... -
Federal
Phorbol esters and CAMP differentially regulate the expression of CD4 and CD8 in human thymocytes
U.S. Department of Health & Human Services —
Background Intrathymic development and selection of the T lymphocyte repertoire is restricted by the interactions of the T cell antigen receptor and CD4 or CD8 co-... -
Federal
Angiotensin receptor blockers in heart failure after the ELITE II trial
U.S. Department of Health & Human Services —
Specific blockers of the angiotensin type1 receptor, angiotensin receptor blockers (ARBs), have been introduced as an alternative to angiotensin-converting enzyme... -
Federal
Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)
U.S. Department of Health & Human Services —
Background Although much is known about the regulation of osteoclast (OC) formation and activity, little is known about OC senescence. In particular, the fate of of... -
Federal
Should all patients receive dual chamber pacing ICDs? The rationale for the DAVID trial
U.S. Department of Health & Human Services —
All of the prospective multicenter trials that support the use of implantable defibrillators have used single chamber pacemakers/implantable cardiovertor...