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Federal
Drug-induced and postnatal hypothyroidism impairs the accumulation of diacylglycerol in liver and liver cell plasma membranes
U.S. Department of Health & Human Services —
Background Thyroid hormones are well known modulators of signal transduction. The effect of hyper- and hypo-thyroidism on diacylglycerol/protein kinase C (DAG/PKC)... -
Federal
The human Y chromosome: the biological role of a “functional wasteland”
U.S. Department of Health & Human Services —
“Functional wasteland,” “Nonrecombining desert,” and “Gene-poor chromosome” are only some examples of the different definitions given to the Y chromosome in the last... -
Federal
Retrovirus-delivered siRNA
U.S. Department of Health & Human Services —
The ability of transfected synthetic small interfering (si) RNAs to suppress the expression of specific transcripts has proved a useful technique to probe gene... -
Federal
What have transgenic and knockout animals taught us about respiratory disease?
U.S. Department of Health & Human Services —
Over the past decade there has been a significant shift to the use of murine models for investigations into the molecular basis of respiratory diseases, including... -
Federal
Transcutaneous flow related variables measured in vivo: the effects of gender
U.S. Department of Health & Human Services —
Backgound The identification of potential sources of error is a crucial step for any new assessment technique. This is the case for transcutaneous variables, such as... -
Federal
Estrogen receptor alpha dinucleotide repeat polymorphism in Japanese patients with autoimmune thyroid diseases
U.S. Department of Health & Human Services —
Background The autoimmune thyroid diseases (AITDs), comprising Graves' disease (GD) and Hashimoto's thyroiditis (HT), appear to develop as a result of complex... -
Federal
Pleasure in decision-making situations
U.S. Department of Health & Human Services —
Background This study explores the role of pleasure in decision making. Results In Experiment 1, 12 subjects were presented with a questionnaire containing 46 items... -
Federal
Debate: Subgroup analyses in clinical trials: fun to look at - but don't believe them!
U.S. Department of Health & Human Services —
Analysis of subgroup results in a clinical trial is surprisingly unreliable, even in a large trial. This is the result of a combination of reduced statistical power,... -
Federal
Phorbol esters and CAMP differentially regulate the expression of CD4 and CD8 in human thymocytes
U.S. Department of Health & Human Services —
Background Intrathymic development and selection of the T lymphocyte repertoire is restricted by the interactions of the T cell antigen receptor and CD4 or CD8 co-... -
Federal
Angiotensin receptor blockers in heart failure after the ELITE II trial
U.S. Department of Health & Human Services —
Specific blockers of the angiotensin type1 receptor, angiotensin receptor blockers (ARBs), have been introduced as an alternative to angiotensin-converting enzyme... -
Federal
Losartan and diabetic nephropathy: commentaries on the RENAAL study
U.S. Department of Health & Human Services —
The RENAAL (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan) study is a multinational, double-blind, randomized, placebo controlled trial... -
Federal
Insertion of a small peptide of six amino acids into the β7–β8 loop of the p51 subunit of HIV-1 reverse transcriptase perturbs the heterodimer and affects its activities
U.S. Department of Health & Human Services —
Background HIV-1 RT is a heterodimeric enzyme, comprising of the p66 and p51 subunits. Earlier, we have shown that the β7-β8 loop of p51 is a key structural element... -
Federal
Debate: Should statin be used in patients with heart failure?
U.S. Department of Health & Human Services —
Statins reduce mortality of patients with coronary artery disease (CAD). However, by protocol, trials have excluded patients with chronic heart failure. Since the... -
Federal
Impaired wound healing in mice deficient in a matricellular protein SPARC (osteonectin, BM-40)
U.S. Department of Health & Human Services —
Background SPARC is a matricellular protein involved in cell-matrix interactions. From expression patterns at the wound site and in vitro studies, SPARC has been... -
Federal
The role of lumbar puncture in children with suspected central nervous system infection
U.S. Department of Health & Human Services —
Background The use of the lumbar puncture in the diagnosis of central nervous system infection in acutely ill children is controversial. Recommendations have been... -
Federal
Unpredicted spontaneous extrusion of a renal calculus in an adult male with spina bifida and paraplegia: report of a misdiagnosis. Measures to be taken to reduce urological errors in spinal cord injury patients
U.S. Department of Health & Human Services —
Background A delay in diagnosis or a misdiagnosis may occur in patients with spinal cord injury (SCI) or spinal bifida as typical symptoms of a clinical condition may... -
Federal
Impact of nosocomial pneumonia on the outcome of mechanically-ventilated patients
U.S. Department of Health & Human Services —
Background: Nosocomial pneumonia (NP) is a common complication in mechanically-ventilated patients and is considered to be one of the most common causes of morbidity... -
Federal
Melatonin reduces TNF-a induced expression of MAdCAM-1 via inhibition of NF-kB.
U.S. Department of Health & Human Services —
Background Endothelial MAdCAM-1 (mucosal addressin cell adhesion molecule-1) expression is associated with the oxidant-dependent induction and progress of... -
Federal
Long termin-vivostudies of a photo-oxidized bovine osteochondral transplant in sheep
U.S. Department of Health & Human Services —
Articular cartilage has limited capacity to repair. Defects greater than 3 mm heal with formation of inferior fibrous cartilage. Therefore, many attempts have been... -
Federal
TheArthritis Researchnon-peer-review depository
U.S. Department of Health & Human Services —
As readers may already be aware, the NIH have declared a plan that invites any journal that wishes to participate to deposit non-peer-reviewed research into PubMed...