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Federal
A simple model based on mutation and selection explains trends in codon and amino-acid usage and GC composition within and across genomes
U.S. Department of Health & Human Services —
Background: Correlations between genome composition (in terms of GC content) and usage of particular codons and amino acids have been widely reported, but poorly... -
Federal
The evolutionary position of nematodes
U.S. Department of Health & Human Services —
Background The complete genomes of three animals have been sequenced by global research efforts: a nematode worm (Caenorhabditis elegans), an insect (Drosophila... -
Federal
Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (
U.S. Department of Health & Human Services —
Background: Differences in responses to bacterial surface lipopolysaccharides (LPSs) are apparent between and within mammalian species. It has been shown in mice that... -
Federal
Evidence for an evolutionarily conserved interaction between cell wall biosynthesis and flowering in maize and sorghum
U.S. Department of Health & Human Services —
Background Factors that affect flowering vary among different plant species, and in the grasses in particular the exact mechanism behind this transition is not fully... -
Federal
Molecular cloning and sequence analysis of hamster CENP-A cDNA
U.S. Department of Health & Human Services —
Background The centromere is a specialized locus that mediates chromosome movement during mitosis and meiosis. This chromosomal domain comprises a uniquely packaged... -
Federal
Potential of (GATA)
U.S. Department of Health & Human Services —
Background The microsatellite, (GATA)n has been frequently used for DNA fingerprinting. However, very few attempts have been made to analyze (GATA)n-containing loci... -
Federal
A ~35 kDa polypeptide from insect cells binds to yeast ACS like elements in the presence of ATP
U.S. Department of Health & Human Services —
Background The S. cerevisiae origin recognition complex binds to the ARS consensus sequence in an ATP dependent fashion. Recently, the yeast Cdc6 has been reported to... -
Federal
Prediction of co-regulated genes in
U.S. Department of Health & Human Services —
Background Identification of co-regulated genes is essential for elucidating transcriptional regulatory networks and the function of uncharacterized genes. Although... -
Federal
Receptorphin: A conserved peptide derived from the sequence of the opioid receptor, with opioid displacement activity and potent antiproliferative actions in tumor cells
U.S. Department of Health & Human Services —
Background In addition to endogenous opioids, a number of peptide sequences, derived from endogenous (hemorphins, alphaS1-casomorphin), and exogenous proteins... -
Federal
Comparative transcription map of the
U.S. Department of Health & Human Services —
Background To support the positional cloning of the mouse mutation wobbler (wr) the corresponding regions on human Chr2p13-14 and mouse Chr11 were analyzed in detail... -
Federal
Research Article: BMC Genomics
U.S. Department of Health & Human Services —
Background Gonadotropin releasing hormone (GnRH) is responsible for stimulation of gonadotropic hormone (GtH) in the hypothalamus-pituitary-gonadal axis (HPG). The... -
Federal
Evolution of gene order conservation in prokaryotes
U.S. Department of Health & Human Services —
Background As more complete genomes are sequenced, conservation of gene order between different organisms is emerging as an informative property of the genomes.... -
Federal
Characterisation and expression of a PP1 serine/threonine protein phosphatase (PfPP1) from the malaria parasite,
U.S. Department of Health & Human Services —
Background Reversible protein phosphorylation is relatively unexplored in the intracellular protozoa of the Apicomplexa family that includes the genus Plasmodium, to... -
Federal
Gene targeting in mosquito cells: a demonstration of 'knockout' technology in extrachromosomal gene arrays
U.S. Department of Health & Human Services —
Background Gene targeting would offer a number of advantages over current transposon-based strategies for insect transformation. These include freedom from both... -
Federal
Survey of human mitochondrial diseases using new genomic/proteomic tools
U.S. Department of Health & Human Services —
Background We have constructed Bayesian prior-based, amino-acid sequence profiles for the complete yeast mitochondrial proteome and used them to develop methods for... -
Federal
Cloning and characterization of the mouse
U.S. Department of Health & Human Services —
Background Mucolipidosis type IV (MLIV) is an autosomal recessive lysosomal storage disorder characterized by severe neurologic and ophthalmologic abnormalities.... -
Federal
Patent AT-E401426-T1: [Translated] METHOD FOR IDENTIFYING BIOLOGICAL SPECIES
U.S. Department of Health & Human Services —
The present invention provides a method for identifying species and subspecies in a biological sample through the selective amplification of segments of nucleic acid... -
Federal
Implications of post-pneumonectomy compensatory lung growth in pulmonary physiology and disease
U.S. Department of Health & Human Services —
In a number of species, partial pneumonectomy initiates hormonally regulated compensatory growth of the remaining lung lobes that restores normal mass, structure and... -
Federal
Evidence for symmetric chromosomal inversions around the replication origin in bacteria
U.S. Department of Health & Human Services —
Background: Whole-genome comparisons can provide great insight into many aspects of biology. Until recently, however, comparisons were mainly possible only between... -
Federal
Identification of the gene encoding Brain Cell Membrane Protein 1 (BCMP1), a putative four-transmembrane protein distantly related to the Peripheral Myelin Protein 22 / Epithelial Membrane Proteins and the Claudins
U.S. Department of Health & Human Services —
Background A partial cDNA clone from dog thyroid presenting a very significant similarity with an uncharacterized mouse EST sequence was isolated fortuitously. We...