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Federal
Elevated nerve growth factor and neurotrophin-3 levels in cerebrospinal fluid of children with hydrocephalus
U.S. Department of Health & Human Services —
Background Elevated intracranial pressure (ICP) resulting from impaired drainage of cerebrospinal fluid (CSF) causes hydrocephalus with damage to the central nervous... -
Federal
Retroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo
U.S. Department of Health & Human Services —
Background Phosphatidylinositol-3,4,5-triphosphate (PtdInsP3) signaling is elevated in many tumors due to loss of the tumor suppressor PTEN, and leads to constitutive... -
Federal
Expression of monolysocardiolipin acyltransferase activity is regulated in concert with the level of cardiolipin and cardiolipin biosynthesis in the mammalian heart
U.S. Department of Health & Human Services —
Background Monolysocardiolipin acyltransferase (MLCL AT) catalyzes the acylation of monolysocardiolipin to cardiolipin in mammalian tissues. We previously reported... -
Federal
Th1 and Th2 cytokines regulate proteoglycan-specific autoantibody isotypes and arthritis
U.S. Department of Health & Human Services —
BALB/c mice immunized with human cartilage proteoglycan (PG) develop arthritis accompanied by the production of autoantibodies to mouse cartilage PG. To determine... -
Federal
Activation of the kinin system in the ovary during ovulation: Role of endogenous progesterone
U.S. Department of Health & Human Services —
Background Previous work by our group and others has implicated a role for kinins in the ovulatory process. The purpose of the present study was to elucidate whether... -
Federal
Anti-TNF-α antibody allows healing of joint damage in polyarthritic transgenic mice
U.S. Department of Health & Human Services —
Anti-tumor-necrosis-factor-α (TNF-α) monoclonal antibody was used to treat Tg197 transgenic mice, which constitutively produce human TNF-α (hTNF-α) and develop a... -
Federal
Digital analysis of cDNA abundance; expression profiling by means of restriction fragment fingerprinting
U.S. Department of Health & Human Services —
Background Gene expression profiling among different tissues is of paramount interest in various areas of biomedical research. We have developed a novel method (DADA,... -
Federal
Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice
U.S. Department of Health & Human Services —
Background Glaucoma is a common disease but its molecular etiology is poorly understood. It involves retinal ganglion cell death and optic nerve damage that is often... -
Federal
HIV-1 expression induces cyclin D
U.S. Department of Health & Human Services —
Background The aberrant cell-cycle progression of HIV-1-infected kidney cells plays a major role in the pathogenesis of HIV-associated nephropathy, however the... -
Federal
Cloning and characterization of the rat homologues of the Inhibitor of Apoptosis protein 1, 2, and 3 genes.
U.S. Department of Health & Human Services —
Background Inhibitor of Apoptosis (IAP) proteins are key intrinsic regulators of apoptosis induced by a variety of triggers. We isolated the rat Inhibitor of... -
Federal
Omapatrilat normalizes renal function curve in spontaneously hypertensive rats
U.S. Department of Health & Human Services —
Background The present study was designed to analyze the chronic renal response to omapatrilat, a new vasopeptidase inhibitor, in spontaneously hypertensive rats... -
Federal
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors
U.S. Department of Health & Human Services —
Matrix metalloproteinase (MMP)-1, MMP-8 and MMP-13 are interstitial collagenases that degrade type II collagen in cartilage; this is a committed step in the... -
Federal
Right and left prefrontal transcranial magnetic stimulation at 1 Hz does not affect mood in healthy volunteers
U.S. Department of Health & Human Services —
Background Prefrontal repetitive transcranial magnetic stimulation (rTMS) has been used to induce side-specific mood changes in volunteers and patients. To clarify... -
Federal
Calcium dynamics during fertilization in
U.S. Department of Health & Human Services —
Background Of the animals typically used to study fertilization-induced calcium dynamics, none is as accessible to genetics and molecular biology as the model... -
Federal
The enhancement of the hyperglycemic effect of S-nitrosoglutathione and S-nitroso-N-acetylpenicillamine by vitamin C in an animal model
U.S. Department of Health & Human Services —
Background S-nitrosoglutathione (GSNO) and S-nitroso-N-acetlypenicillamine (SNAP) are two of the most common sources of nitric oxide (NO) in the biomedical field.... -
Federal
Elevated serum immunoglobulin E to
U.S. Department of Health & Human Services —
Background The possible participation of diesel exhaust inhalation during the fetal period in the elevation of IgE against pollen in postnatal life was investigated.... -
Federal
A new era in hypertension research: discussing the findings of ALLHAT
U.S. Department of Health & Human Services —
The key question in hypertension research today is, "Does it matter how elevated blood pressure is lowered?" The Antihypertensive and Lipid-Lowering Treatment to... -
Federal
Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis
U.S. Department of Health & Human Services —
Background: Increased serum levels of procalcitonin (ProCT) and its component peptides have been reported in humans with sepsis. Using a hamster model of bacterial... -
Federal
Nitric oxide: a pro-inflammatory mediator in lung disease?
U.S. Department of Health & Human Services —
Inflammatory diseases of the respiratory tract are commonly associated with elevated production of nitric oxide (NO•) and increased indices of NO• -dependent...