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Federal
Time course of muscle soreness following different types of exercise
U.S. Department of Health & Human Services —
Background Post-exercise muscle soreness is a dull, aching sensation that follows unaccustomed muscular exertion. Primarily on the basis of previous laboratory-based... -
Federal
Internet hand x-rays: A comparison of joint space narrowing and erosion scores (Sharp/Genant) of plain versus digitized x-rays in rheumatoid arthritis patients
U.S. Department of Health & Human Services —
Background The objective of the study is to examine the reliability of erosion and joint space narrowing scores derived from hand x-rays posted on the Internet... -
Federal
Genetic epidemiology: Systemic lupus erythematosus
U.S. Department of Health & Human Services —
Systemic lupus erythematosus is the prototype multisystem autoimmune disease. A strong genetic component of susceptibility to the disease is well established. Studies... -
Federal
Reporting of conflicts of interest in guidelines of preventive and therapeutic interventions
U.S. Department of Health & Human Services —
Background Guidelines published in major medical journals are very influential in determining clinical practice. It would be essential to evaluate whether conflicts... -
Federal
Tumour Fas ligand:Fas ratio greater than 1 is an independent marker of relative resistance to tamoxifen therapy in hormone receptor positive breast cancer
U.S. Department of Health & Human Services —
Background The objective of the present study was to examine the prognostic and predictive significance of the apoptosis-related marker Fas ligand (FasL):Fas ratio in... -
Federal
Use of complementary/alternative therapies by women with advanced-stage breast cancer
U.S. Department of Health & Human Services —
Background This study sought to describe the pattern of complementary/alternative medicine (CAM) use among a group of patients with advanced breast cancer, to examine... -
Federal
Oral sildenafil (Viagra™) in male erectile dysfunction: use, efficacy and safety profile in an unselected cohort presenting to a British district general hospital.
U.S. Department of Health & Human Services —
Introduction Sildenafil (Viagra®) is one of the drugs used in the first line therapy of male erectile dysfunction (MED). We have recorded outcomes, adverse events and... -
Federal
Bone mineral density and the subsequent risk of cancer in the NHANES I follow-up cohort
U.S. Department of Health & Human Services —
Backgroud Bone mineral density (BMD) is a marker of long-term estrogen exposure. BMD measurement has been used in this context to investigate the association of... -
Federal
Molecular action of methotrexate in inflammatory diseases
U.S. Department of Health & Human Services —
Despite the recent introduction of biological response modifiers and potent new small-molecule antirheumatic drugs, the efficacy of methotrexate is nearly unsurpassed... -
Federal
Association of Down's syndrome and water fluoride level: a systematic review of the evidence
U.S. Department of Health & Human Services —
Background A review of the safety and efficacy of drinking water fluoridation was commissioned by the UK Department of Health to investigate whether the evidence... -
Federal
A clustering method for repeat analysis in DNA sequences
U.S. Department of Health & Human Services —
Background A computational system for analysis of the repetitive structure of genomic sequences is described. The method uses suffix trees to organize and search the... -
Federal
Beta-Adrenergic gene therapy for cardiovascular disease
U.S. Department of Health & Human Services —
Gene therapy using in vivo recombinant adenovirus-mediated gene transfer is an effective technique that offers great potential to improve existing drug treatments for... -
Federal
Optimizing antibiotic therapy in the intensive care unit setting
U.S. Department of Health & Human Services —
Antibiotics are one of the most common therapies administered in the intensive care unit setting. In addition to treating infections, antibiotic use contributes to... -
Federal
Polymorphisms in the
U.S. Department of Health & Human Services —
Background Oxidative stress, resulting in a marked increase in the level of oxygen free radicals (OFR), has been implicated in the etiology of diabetic neuropathy... -
Federal
Case-oriented computer-based-training in radiology: concept, implementation and evaluation
U.S. Department of Health & Human Services —
Background Providing high-quality clinical cases is important for teaching radiology. We developed, implemented and evaluated a program for a university hospital to... -
Federal
Risk factors for acquisition of hepatitis C virus infection: a case series and potential implications for disease surveillance
U.S. Department of Health & Human Services —
Background Transmission of hepatitis C vims (HCV) is strongly associated with use of contaminated blood products and injection drugs. Other "non-parental" modes of... -
Federal
Hormone replacement therapy and prevention of vertebral fractures: a meta-analysis of randomised trials
U.S. Department of Health & Human Services —
Background Hormone replacement therapy (HRT) is often seen as the treatment of choice for preventing fractures in women. We undertook a recent meta-analysis of... -
Federal
Breast cancer mortality among Ashkenazi Jewish women in São Paulo and Porto Alegre, Brazil
U.S. Department of Health & Human Services —
Background Increased BRCA1 and BRCA2 germline mutation rates have been reported in Ashkenazi Jewish women in North America, Europe and Israel, and have been mentioned... -
Federal
Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation
U.S. Department of Health & Human Services —
Cytokines play a critical role in the normal development and function of the immune system. On the other hand, many rheumatologic diseases are characterized by poorly... -
Federal
Four signature motifs define the first class of structurally related large coiled-coil proteins in plants.
U.S. Department of Health & Human Services —
Background Animal and yeast proteins containing long coiled-coil domains are involved in attaching other proteins to the large, solid-state components of the cell....