These data were collected under a cooperative mapping program between the U.S. Geological Survey (USGS), the National Oceanic and Atmospheric Administration Coastal Services Center (NOAA\CSC), and the Apalachicola National Estuarine Research Reserve (NERR). The primary objectives of this program are to collect marine geophysical data and develop a suite of seafloor maps to better define the extent of oyster habitats and the overall seafloor geology of the bay to provide updated information for management of this resource. In addition to their value for management of the bay's oyster resources, the maps also provide a geologic framework for scientific research and the public. High-resolution bathymetry, backscatter intensity, and seismic profile data were collected over a 76 square kilometer area covering the deeper (>2.0 m) portions of St. George Sound to characterize the surface and subsurface of Apalachicola Bay and St. George Sound for geologic framework investigations.