Dataset is about Operation Chain Breaker (OCB) which is an initiative targeting Chinese pill press manufacturers and the Mexican Transnational Crime Organizations (TCOs) using pill press equipment to mass produce fentanyl pills being smuggled into the United States. OCB is one of three nationally branded DHS/HSI National Opioid Strategy Initiatives, which is focused on Chinese pill press supply chains; Mexican pill press brokers; Mexican TCOs using pill press equipment to mass produce fentanyl and fentanyl-related substances; domestic pill press equipment recipients engaged in fentanyl and fentanyl-related substance production; and money launderers facilitating the movement of fentanyl proceeds. During FY 2023, OCB sent over 172 collateral case requests and/or investigative referrals. Since its inception in 2021, OCB leads have resulted in the dismantlement of 15 domestic fentanyl labs and the seizures of over 400 pounds of fentanyl and fentanyl-related substances, 2,000 pounds of fentanyl precursors, and over 2,000 pieces of pill press equipment.