Serum proteomics of coronavirus shedding in vampire bats (Desmodus rotundus)

Published by National Institute of Standards and Technology | National Institute of Standards and Technology | Catalog Last Checked: August 03, 2026 at 03:51 AM | Dataset Last Updated: January 19, 2022

Bats can harbor many pathogens without showing disease. However, the mechanisms by which bats resolve these infections or limit pathology remain unclear. To illuminate the bat immune response to coronaviruses, viruses with high public health significance, we will use serum proteomics to assess broad differences in immune proteins of uninfected and infected vampire bats (Desmodus rotundus). In contrast to global profiling techniques of blood such as transcriptomics, proteomics provides a unique perspective into immunology, as the serum proteome includes proteins from not only blood but also those secreted from proximal tissues. Here, we expand our recent work on the serum proteome of wild vampire bats (Desmodus rotundus) to better understand CoV pathogenesis. Across 19 bats sampled in 2019 in northern Belize with available sera, we detected CoVs in oral or rectal swabs from four individuals. We used data independent acquisition-based mass spectrometry to profile and compare the undepleted serum proteome of these 19 bats. These results will provide much needed insight into changes in the bat serum proteome in response to coronavirus infection.

Resources

68 resources available

Resource 1

BIN

Download
Resource 2

TXT

Download
Resource 3

BIN

Download
Resource 4

TXT

Download
Resource 5

BIN

Download
Resource 6

TXT

Download
Resource 7

BIN

Download
Resource 8

TXT

Download
Resource 9

BIN

Download
Resource 10

TXT

Download
Resource 11

BIN

Download
Resource 12

TXT

Download
Resource 13

BIN

Download
Resource 14

TXT

Download
Resource 15

BIN

Download
Resource 16

TXT

Download
Resource 17

BIN

Download
Resource 18

TXT

Download
Resource 19

BIN

Download
Resource 20

TXT

Download
Resource 21

BIN

Download
Resource 22

TXT

Download
Resource 23

BIN

Download
Resource 24

TXT

Download
Resource 25

BIN

Download
Resource 26

TXT

Download
Resource 27

BIN

Download
Resource 28

TXT

Download
Resource 29

BIN

Download
Resource 30

TXT

Download
Resource 31

BIN

Download
Resource 32

TXT

Download
Resource 33

BIN

Download
Resource 34

TXT

Download
Resource 35

BIN

Download
Resource 36

TXT

Download
Resource 37

BIN

Download
Resource 38

TXT

Download
Resource 39

BIN

Download
Resource 40

TXT

Download
Resource 41

BIN

Download
Resource 42

TXT

Download
Resource 43

BIN

Download
Resource 44

TXT

Download
Resource 45

BIN

Download
Resource 46

TXT

Download
Resource 47

BIN

Download
Resource 48

TXT

Download
Resource 49

BIN

Download
Resource 50

TXT

Download
Resource 51

BIN

Download
Resource 52

TXT

Download
Resource 53

BIN

Download
Resource 54

TXT

Download
Resource 55

BIN

Download
Resource 56

TXT

Download
Resource 57

BIN

Download
Resource 58

TXT

Download
Resource 59

BIN

Download
Resource 60

TXT

Download
Resource 61

BIN

Download
Resource 62

TXT

Download
Resource 63

XLSX

Download
Resource 64

TXT

Download
Resource 65

BIN

Download
Resource 66

TXT

Download
Resource 67

BIN

Download
Resource 68

TXT

Download

Find Related Datasets

Search by Tags

Click any tag below to search for similar datasets

Complete Metadata

@type	dcat:Dataset
accessLevel	public
accrualPeriodicity	irregular
bureauCode	[ "006:55" ]
contactPoint	{ "fn": "Ben Neely", "hasEmail": "mailto:benjamin.neely@nist.gov" }
description	Bats can harbor many pathogens without showing disease. However, the mechanisms by which bats resolve these infections or limit pathology remain unclear. To illuminate the bat immune response to coronaviruses, viruses with high public health significance, we will use serum proteomics to assess broad differences in immune proteins of uninfected and infected vampire bats (Desmodus rotundus). In contrast to global profiling techniques of blood such as transcriptomics, proteomics provides a unique perspective into immunology, as the serum proteome includes proteins from not only blood but also those secreted from proximal tissues. Here, we expand our recent work on the serum proteome of wild vampire bats (Desmodus rotundus) to better understand CoV pathogenesis. Across 19 bats sampled in 2019 in northern Belize with available sera, we detected CoVs in oral or rectal swabs from four individuals. We used data independent acquisition-based mass spectrometry to profile and compare the undepleted serum proteome of these 19 bats. These results will provide much needed insight into changes in the bat serum proteome in response to coronavirus infection.
distribution	[ { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_10.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_10.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_12.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_12.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_13.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_13.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_14.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_14.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_15.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_15.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_16.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_16.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_16H.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_16H.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_16NH.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_16NH.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_17.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_17.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_18.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_18.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_19.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_19.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_2.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_2.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_20.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_20.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_20H.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_20H.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_20NH.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_20NH.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_21.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_21.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_22.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_22.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_23.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_23.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_3.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_3.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_5.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_5.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_5H.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_5H.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_5NH.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_5NH.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_6.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_6.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_7.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_7.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_7H.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_7H.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_7NH.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_7NH.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_8.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_8.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_9.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_9.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_pool1.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_pool1.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_pool2.raw" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/2021-7-13_BatCov_pool2.raw.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/85min_DIA_40x21mz.meth" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/85min_DIA_40x21mz.meth.sha256" }, { "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/DataKey.xlsx" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/DataKey.xlsx.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/RefSeq_Vampire_Bat_100_GCF_002940915.1_ASM294091v2_protein.fasta" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/RefSeq_Vampire_Bat_100_GCF_002940915.1_ASM294091v2_protein.fasta.sha256" }, { "mediaType": "application/octet-stream", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/uniprot-all_Coronaviridae-11118_2021_03.fasta" }, { "mediaType": "text/plain", "downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2556/uniprot-all_Coronaviridae-11118_2021_03.fasta.sha256" } ]
identifier	ark:/88434/mds2-2556
issued	2022-12-02
keyword	[ "Alphacoronavirus", "Desmodus rotundus", "biomarker", "ecoimmunology", "proteome" ]
landingPage	https://data.nist.gov/od/id/mds2-2556
language	[ "en" ]
license	https://www.nist.gov/open/license
modified	2022-01-19 00:00:00
programCode	[ "006:045" ]
publisher	{ "name": "National Institute of Standards and Technology", "@type": "org:Organization" }
theme	[ "Bioscience:Proteomics" ]
title	Serum proteomics of coronavirus shedding in vampire bats (Desmodus rotundus)

Have questions or suggestions about this dataset? Reach out to the contact below.