Patent AT-E401305-T1: [Translated] SYNTHESIS OF HETEROCYCLIC COMPOUNDS WHICH CONTAIN FIVE OR SIX RINGS
The following are claimed: (A) anthracycline compounds of formula Q-O-R-P (I) Q = a group of formula (i):R = H (sic) or C(O)-(CH2)n-C(O);n = 0-7;R' = NH2; or an aromatic or hydrogenated 5 or 6 membered heterocycle having at least one ring nitrogen, optionally having a butadiene moiety bonded to adjacent carbon atoms to form a bicyclic system;P = H or a peptide; Provided that: (a) where R' is NH2, then R and P are other than H; and (b) where R and P are H, then R' is other than NH2. (B) Conversion of the nitrogen of a primary amino group of an ~a,~b- or ~a,~c-hydroxy primary amine into the nitrogen of a monounsaturated nitrogen-containing heterocyclic compound having 5-6 ring atoms, comprising: (a) treating the hydroxy amine with an excess of a haloaldehyde having an aldehyde carbon, a halo-bearing carbon and having 2 or 3 moieties between the aldehyde carbon and the halo-bearing carbon selected from CH2, CH2CH2 and OCH2; (b) adding an excess (relative to the hydroxyamine) of an organic base; (c) neutralising the base with a weak acid; and (d) treating with a dilute aqueous acid. X' = halo; Y = CH2, OCH2 or CH2-CH2; Z is absent or is CH2.
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| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "009:25" ] |
| contactPoint |
{ "fn": "NIH/NCBI Data Team", "@type": "vcard:Contact", "hasEmail": "mailto:info@ncbi.nlm.nih.gov" } |
| description | The following are claimed: (A) anthracycline compounds of formula Q-O-R-P (I) Q = a group of formula (i):R = H (sic) or C(O)-(CH2)n-C(O);n = 0-7;R' = NH2; or an aromatic or hydrogenated 5 or 6 membered heterocycle having at least one ring nitrogen, optionally having a butadiene moiety bonded to adjacent carbon atoms to form a bicyclic system;P = H or a peptide; Provided that: (a) where R' is NH2, then R and P are other than H; and (b) where R and P are H, then R' is other than NH2. (B) Conversion of the nitrogen of a primary amino group of an ~a,~b- or ~a,~c-hydroxy primary amine into the nitrogen of a monounsaturated nitrogen-containing heterocyclic compound having 5-6 ring atoms, comprising: (a) treating the hydroxy amine with an excess of a haloaldehyde having an aldehyde carbon, a halo-bearing carbon and having 2 or 3 moieties between the aldehyde carbon and the halo-bearing carbon selected from CH2, CH2CH2 and OCH2; (b) adding an excess (relative to the hydroxyamine) of an organic base; (c) neutralising the base with a weak acid; and (d) treating with a dilute aqueous acid. X' = halo; Y = CH2, OCH2 or CH2-CH2; Z is absent or is CH2. |
| distribution |
[ { "@type": "dcat:Distribution", "title": "Official Data Source", "mediaType": "text/html", "description": "Access the complete Patent AT-E401305-T1: [Translated] SYNTHESIS OF HETEROCYCLIC COMPOUNDS WHICH CONTAIN FIVE OR SIX RINGS on the official website.", "downloadURL": "https://pubchem.ncbi.nlm.nih.gov/patent/AT-E401305-T1" } ] |
| identifier | https://healthdata.gov/api/views/ta7e-7nxa |
| issued | 2025-09-05 |
| keyword |
[ "chemistry", "innovation", "patent", "pubchem", "research" ] |
| landingPage | https://healthdata.gov/d/ta7e-7nxa |
| modified | 2025-09-06 |
| programCode |
[ "009:066" ] |
| publisher |
{ "name": "National Center for Biotechnology Information (NCBI)", "@type": "org:Organization" } |
| theme |
[ "NIH" ] |
| title | Patent AT-E401305-T1: [Translated] SYNTHESIS OF HETEROCYCLIC COMPOUNDS WHICH CONTAIN FIVE OR SIX RINGS |
