Here, we provide the first global geodatabase of non-floodplain wetlands. We incorporate the recent development of a high-resolution global floodplain mapping algorithm based on digital terrain models by Nardi et al. (2019). We couple these spatial floodplain data with higher-resolution modifications to the gridded global wetland and open water data layers developed by Tootchi et al. (2019) that incorporates the Pekel et al. (2016) satellite-based inundation product, modeled groundwater-driven wetland extent (Fan et al. 2013), and ancillary satellite landcover data from Herold et al. (2015). We test the applicability of our global database of non-floodplain wetlands in 21 large and spatial-data rich watersheds across the CONUS. This novel global product identifying non-floodplain wetlands provides for the quantification and estimation of the locations and extent of important aquatic systems with abundant hydrological, biogeochemical, and biological functions, filling a noted research gap while delivering useful data for informed natural resource decision-making and management (Creed et al. 2017, Lane et al. 2022).