The dataset provides a spatially explicit estimate of 2019 herbaceous annual percent cover predicted on May 1st with an emphasis on annual grasses. The estimate is based on the mean output of two regression-tree models. For one model, we include, as an independent variable amongst other independent variables, a dataset that is the mean of 17-years of annual herbaceous percent cover (https://doi.org/10.5066/F71J98QK). This model's test mean error rate (n = 1670), based on nine different randomizations, equals 4.9% with a standard deviation of +/- 0.15. A second model was developed that did not include the mean of 17-years of annual herbaceous percent cover, and this model's test mean error rate (n = 1670), based on nine different randomizations, equals 5.0% with a standard deviation of +/- 0.11. The mean value for each pixel represents the May 2019 early estimate of annual herbaceous percent cover. The pixel values for the merged 2019 dataset range from 0 to100 percent cover with an overall mean value of 11.20 and a standard deviation of +/-9.77. This dataset is generated by integrating ground-truth measurements of annual herbaceous percent cover with 250-m spatial resolution eMODIS NDVI satellite derived data and geophysical variables into regression-tree software. The geographic coverage includes the Great Basin, the Snake River Plain, the state of Wyoming, and contiguous areas. We applied a mask to areas above 2250-m elevation because annual grasses are unlikely to exist at substantial cover above this threshold. To target likely sagebrush ecosystems, the mask also hid pixels classified as something other than shrub or grassland/herbaceous by the 2011 National Land Cover Dataset (NLCD). Cheatgrass (Bromus tectorum) is the most common annual grass in the study area. It grows from seed, usually in spring, matures quickly, produces seed, and dies. After dying, cheatgrass contributes fine fuels that facilitate fire ignition and spread throughout sagebrush ecosystems. These fires remove sagebrush stands. Increasing fire frequencies, land management practices, and development have all contributed to the fragmentation of the once expansive sagebrush ecosystems. These ecosystems are critical for water quality, reduced fire threats, and the survival of sagebrush-dependent wildlife.