Bioactivity of the ubiquitous tire preservative 6PPD and degradant, 6PPD-quinone in fish and mammalian-based assays
The data set contains data for the following assays performed using 6PPD-quinone and/or 6PPD. 1) Larval fathead minnow transcriptomics; 2) larval fathead minnow EcoToxChips [6PPD-quinone only]; 3) zebrafish developmental and behavioral toxicity; 4) cell painting and cytotoxicity in the rainbow trout gill cell line, RTgill-W1; 5) acute and developmental neurotoxicity (DNT) assays in mammalian cells; 6) Attagene FACTORIAL assays with human hepatoma cells [6PPD-quinone only]; and 7) analytical assessment of 6PPD and 6PPD-quinone stability in RTgill-W1 and DNT assay media.
This dataset is associated with the following publication:
Jankowski, M., A. Carpenter, J. Harrill, D. Harris, B. Hill, R. Labiosa, S. Makarov, D. Martinovic-Weigelt, J. Nyffeler, S. Padilla, T. Shafer, M. Smeltz, and D. Villeneuve. Bioactivity of the ubiquitous tire preservative 6PPD and degradant, 6PPD-quinone in fish- and mammalian-based assays. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 204(2): 198-217, (2025).
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https://clowder.edap-cluster.com/datasets/677ab279e4b0a7c65d3994d3
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "020:00" ] |
| contactPoint |
{ "fn": "Daniel Villeneuve", "hasEmail": "mailto:villeneuve.dan@epa.gov" } |
| description | The data set contains data for the following assays performed using 6PPD-quinone and/or 6PPD. 1) Larval fathead minnow transcriptomics; 2) larval fathead minnow EcoToxChips [6PPD-quinone only]; 3) zebrafish developmental and behavioral toxicity; 4) cell painting and cytotoxicity in the rainbow trout gill cell line, RTgill-W1; 5) acute and developmental neurotoxicity (DNT) assays in mammalian cells; 6) Attagene FACTORIAL assays with human hepatoma cells [6PPD-quinone only]; and 7) analytical assessment of 6PPD and 6PPD-quinone stability in RTgill-W1 and DNT assay media. This dataset is associated with the following publication: Jankowski, M., A. Carpenter, J. Harrill, D. Harris, B. Hill, R. Labiosa, S. Makarov, D. Martinovic-Weigelt, J. Nyffeler, S. Padilla, T. Shafer, M. Smeltz, and D. Villeneuve. Bioactivity of the ubiquitous tire preservative 6PPD and degradant, 6PPD-quinone in fish- and mammalian-based assays. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 204(2): 198-217, (2025). |
| distribution |
[ { "title": "https://clowder.edap-cluster.com/datasets/677ab279e4b0a7c65d3994d3", "accessURL": "https://clowder.edap-cluster.com/datasets/677ab279e4b0a7c65d3994d3" } ] |
| identifier | https://doi.org/10.23719/1531917 |
| keyword |
[ "Ambient Water", "New Approach Methods (Alternatives to Animal Testing)", "bioactivity", "chemicals", "computational toxicology" ] |
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2025-01-10 |
| programCode |
[ "020:000" ] |
| publisher |
{ "name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": { "name": "U.S. Environmental Protection Agency", "subOrganizationOf": { "name": "U.S. Government" } } } |
| references |
[ "https://doi.org/10.1093/toxsci/kfaf008", "https://pasteur.epa.gov/uploads/10.23719/1531917/documents/Jankowski%20et%20al_Data%20availability%20summary.docx" ] |
| rights |
null
|
| title | Bioactivity of the ubiquitous tire preservative 6PPD and degradant, 6PPD-quinone in fish and mammalian-based assays |
