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Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization

Published by U.S. EPA Office of Research and Development (ORD) | U.S. Environmental Protection Agency | Catalog Last Checked: August 03, 2026 at 12:47 AM | Dataset Last Updated: May 08, 2019
The supplemental information for this paper includes chemical-specific analytical methods, raw instrument data for chemical concentration analysis, processed data for experiments on intrinsic hepatic clearance (CLint -- metabolism) and chemical fraction unbound in the presence of human plasma protein (fup). Figures showing the curve fits for determining CLint are provided. Finally, all data were released publicly as HTTK R Package v1.10.1. This dataset is associated with the following publication: Wambaugh, J., B. Wetmore, C. Ring, C. Nicolas, R. Pearce, G. Honda, R. Dinallo, D. Angus, J. Gilbert, T. Sierra, A. Badrinarayanan, B. Snodgrass, A. Brockman, C. Strock, R. Setzer, and R. Thomas. Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 172(2): 235-251, (2019).

Resources

7 resources available

  • https://cran.r-project.org/package=httk

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  • https://www.epa.gov/chemical-research/toxicity-forecaster-toxcasttm-data

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  • SupTable1-AnalyticalMethods.xlsx

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  • SupTable2-RawPPBData.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • SupTable3-RawCLintData.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • SupTable4-ProcessedData.xlsx

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  • SupplementalFigures4.pdf

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Complete Metadata
accessLevel public
bureauCode 
[
  "020:00"
]
contactPoint 
{
  "fn": "John Wambaugh",
  "hasEmail": "mailto:wambaugh.john@epa.gov"
}
description The supplemental information for this paper includes chemical-specific analytical methods, raw instrument data for chemical concentration analysis, processed data for experiments on intrinsic hepatic clearance (CLint -- metabolism) and chemical fraction unbound in the presence of human plasma protein (fup). Figures showing the curve fits for determining CLint are provided. Finally, all data were released publicly as HTTK R Package v1.10.1. This dataset is associated with the following publication: Wambaugh, J., B. Wetmore, C. Ring, C. Nicolas, R. Pearce, G. Honda, R. Dinallo, D. Angus, J. Gilbert, T. Sierra, A. Badrinarayanan, B. Snodgrass, A. Brockman, C. Strock, R. Setzer, and R. Thomas. Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 172(2): 235-251, (2019).
distribution 
[
  {
    "title": "https://cran.r-project.org/package=httk",
    "accessURL": "https://cran.r-project.org/package=httk"
  },
  {
    "title": "https://www.epa.gov/chemical-research/toxicity-forecaster-toxcasttm-data",
    "accessURL": "https://www.epa.gov/chemical-research/toxicity-forecaster-toxcasttm-data"
  },
  {
    "title": "SupTable1-AnalyticalMethods.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1504435/SupTable1-AnalyticalMethods.xlsx"
  },
  {
    "title": "SupTable2-RawPPBData.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1504435/SupTable2-RawPPBData.xlsx"
  },
  {
    "title": "SupTable3-RawCLintData.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1504435/SupTable3-RawCLintData.xlsx"
  },
  {
    "title": "SupTable4-ProcessedData.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1504435/SupTable4-ProcessedData.xlsx"
  },
  {
    "title": "SupplementalFigures4.pdf",
    "mediaType": "application/pdf",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1504435/SupplementalFigures4.pdf"
  }
]
identifier https://doi.org/10.23719/1504435
keyword 
[
  "ExpoCast",
  "exposure"
]
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2019-05-08
programCode 
[
  "020:095"
]
publisher 
{
  "name": "U.S. EPA Office of Research and Development (ORD)",
  "subOrganizationOf": {
    "name": "U.S. Environmental Protection Agency",
    "subOrganizationOf": {
      "name": "U.S. Government"
    }
  }
}
references 
[
  "https://doi.org/10.1093/toxsci/kfz205"
]
rights 
null
title Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization

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