Agonizing Hedgehog
It is a rare treat when a drug discovery program teaches us something about the biology of the process that it attempts to modulate. The paper by Maria Frank-Kamenetsky and colleagues in this issue of theJournal of Biology[1] presents a compelling example of how the search for therapeutics can provide powerful experimental tools and insights into fundamental biology, blurring the distinction between applied and basic research. By characterizing a small group of chemically similar agonists of theHedgehogsignaling pathway, Frank-Kamenetskyet al. have been able to propose a new model for how theSmoothenedcomponent of the Hedgehog-receptor complex works, and to hint at the existence of natural-ligand agonists of the Hedgehog signaling pathway (see'The bottom line'box for a summary of their work).
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "009:25" ] |
| contactPoint |
{ "fn": "NIH", "@type": "vcard:Contact", "hasEmail": "mailto:info@nih.gov" } |
| description | It is a rare treat when a drug discovery program teaches us something about the biology of the process that it attempts to modulate. The paper by Maria Frank-Kamenetsky and colleagues in this issue of theJournal of Biology[1] presents a compelling example of how the search for therapeutics can provide powerful experimental tools and insights into fundamental biology, blurring the distinction between applied and basic research. By characterizing a small group of chemically similar agonists of theHedgehogsignaling pathway, Frank-Kamenetskyet al. have been able to propose a new model for how theSmoothenedcomponent of the Hedgehog-receptor complex works, and to hint at the existence of natural-ligand agonists of the Hedgehog signaling pathway (see'The bottom line'box for a summary of their work). |
| distribution |
[ { "@type": "dcat:Distribution", "title": "Official Government Data Source", "mediaType": "text/html", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137067/" } ] |
| identifier | https://healthdata.gov/api/views/7jhn-i4gt |
| issued | 2025-07-14 |
| keyword |
[ "agonist-identification", "chemical-genetics", "degenerative-diseases", "hedgehog-signaling", "nih" ] |
| landingPage | https://healthdata.gov/d/7jhn-i4gt |
| modified | 2025-09-29 |
| programCode |
[ "009:033" ] |
| publisher |
{ "name": "National Institutes of Health", "@type": "org:Organization" } |
| theme |
[ "NIH" ] |
| title | Agonizing Hedgehog |
